肺癌、乳腺癌患者外周血淋巴細胞體外MTT法藥敏試驗的研究.pdf

1、石河子大學碩士學位論文肺癌、乳腺癌患者外周血淋巴細胞體外MTT法藥敏試驗的研究姓名：孫凌申請學位級別：碩士專業(yè)：腫瘤學指導教師：鞏平20090401AbstractPurDosethesubjectusingMTTmethodtoselectthesensitivedrugtolungcancerandbreastcancerpatientsandcomparetotheconventionalchemotherapyWewishtoe

2、xploretherelevanceofthetwoanditsclinicalsignificance，withaviewtoimprovecancerefficacyandsurvivalrateofpatientstOavoidunnecessarysideeffects，andprovideatheoreticalbasisforclinicalchemotherapyindividualMethods：select40case

3、swithmalignanttumors，usingMTTmethodtomeasuredPBUssensitivitytoeightkindschemotherapydrugs，thenchoosethesensitivedrugto”individuation”ofchemotherapyInanotherselect48casesoflungcancerandbreastcancerpatientsasacontrolgroup，

4、whichdoesnottakedrugsensitivitytest，butUSetheconventionalchemotherapyFinallyevalutetheeffectofthetwogroup，whetherthereisstatisticallysignificancecomparedbetweenthetwogroupsB髦逝IThechemosensitivityorderforlungcancerwhichis

5、DDPtaxinol，Gemcitabine，carboplatin，vinorelbine，Cytoxan，fluorouracil，ADM；ThechemosensitivityorderformammarycancerwhichisCytoxan，ADM，fluorouracil，taxinol，DDPcarboplatin，Gemcitabine，vinorelbine2Thetherapeuticeffectsofthetes

6、tgroupis871％，thereisstatisticalsignificancecompared謝mthecontrolgroup(55％)(P=O004)3Inthelungcancergroup，thereissignificantdifferencebetweenthetwogroupswithdifferentstagesoftreatment(P005)4InthelungCanCergroup，selectthejoi

7、ntprogramsaccordingtodrugsensitivityresults，theclinicalefficiencyhasincreasedsignificantly(P005)，butinthetestgroup，thereis25％chooseotherwaysofdrugselectioncomparetothecontrolgroup，andtheclinicalefficiencyhasthestatistica

8、lsignificancebetweenthetwogroups5Thereisnoobviousdifference(P005)betweenthetwogroupabouthalfanyearand1yearsurvivalrateWethinkitresultfortakingasafewerexampleandshorterfollowup，SOweshouldexpandthesamplesizeandincreasealon

9、gerperiodofcomparativestudyofsurvival6Chooseallthepatientswhoseclinicalefficiencywas0(exceptthedeathofpatients)，for21cases，takentheirperipheralbloodsamples，andusetheMTTmethodtomeasuredrugsensitivityresultswere鸛follows：al

10、mostthepatientschoosethedrugwhichsensitivitytestshowedthatnonsensitivedrugsC—————o———n———c——lusion——“1Inthispapertheresearchaboutsensitivesequenceoflungcancerto8kindsofcommonlyusedclinicalchemotherapydrugsbasicallyconsis